Activity of Sulopenem, an Oral Penem, against Urinary Isolates of .

The activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC) and 90% (MIC) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml. The activity of sulopenem was unaffected by nonsusceptibility to trimethoprim-sulfamethoxazole and/or ciprofloxacin, multidrug-resistant phenotypes, extended-spectrum β-lactamases, or AmpC β-lactamases.