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Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network. | LitMetric

Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.

Cancer Invest

The Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, USA.

Published: November 2018

AI Article Synopsis

Article Abstract

Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGFβ1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of the promoter and physical interaction of p53. The promoter has binding sites for Egr proteins, and is a target for Dmp1. Crosstalks between p53 and PTEN have been reported. The Egr1-Dmp1-Arf-p53-Pten pathway displays multiple modes of interaction with each other, suggesting the existence of a functional network of tumor suppressors that maintain normal cell growth and prevent the emergence of incipient cancer cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500763PMC
http://dx.doi.org/10.1080/07357907.2018.1533965DOI Listing

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