AI Article Synopsis
- * CanineCV DNA was detected in 81 of 926 serum samples from Guangxi Province, and full genomes were sequenced, revealing a high genetic identity among samples (84.9%-100%).
- * The findings indicate two genotypes of CanineCV (CanineCV-1 and CanineCV-2) and highlight nine significant areas of variation in the capsid protein, enhancing understanding of CanineCV's molecular epidemiology.
Article Abstract
Since the first description of canine circovirus (CanineCV)-associated infection, there have been several reports on the distribution of the disease in worldwide. To investigate the prevalence and genetic diversity of CanineCV in China, we conducted PCR screening of 1226 dog serum samples collected from different regions in mainland China between 2014 and 2016. CanineCV DNA was found in 81/926 serum samples from Guangxi Province. Furthermore, 25 full-length genomes of CanineCV from positive samples were sequenced and compared with CanineCV sequences in the GenBank database. Pairwise analysis showed that the determined genome sequences shared 84.9%-100% identity among themselves and 81.4%-90.5% with the other 28 sequences. Phylogenetic analysis revealed that the 52 viral genome sequences could be divided into two genotypes (CanineCV-1 and CanineCV-2). Analysis of the amino acid sequences of the capsid protein revealed the existence of 9 major regions of variation. The present work contributes to the understanding of CanineCV molecular epidemiology.
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| http://dx.doi.org/10.1016/j.virusres.2018.10.021 | DOI Listing |
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