Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium purpurogenum IMM003. The structures and absolute configurations of 1-3 were established by spectroscopic analysis, single-crystal X-ray diffraction, and calculations of the C NMR and ECD data. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase.
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| http://dx.doi.org/10.1021/acs.orglett.8b03323 | DOI Listing |
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