AI Article Synopsis
- The study investigates the effects of allergen immunotherapy (AIT) on young children with house dust mite sensitivity, highlighting its potential for preventing allergy and asthma development.
- Researchers used high-density peptide arrays to analyze changes in immune response over a 2-year period, finding that AIT led to increased IgG epitope diversity without affecting IgE levels.
- The results suggest that sublingual AIT could improve immune modulation by broadening the body's ability to block allergens and prevent the progression of allergic reactions.
Article Abstract
Background: The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impact on epitope diversity remains to be defined.
Methods: We used high-density peptide arrays that included all known Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) allergens and the whole proteome of Der f to study changes in House Dust Mite (HDM) linear peptide recognition during a 2-year preventive double-blind placebo-controlled sublingual HDM AIT pilot study in 2-5-year-old children with sensitization to HDM but without symptoms.
Results: Preventive AIT-treated patients showed significantly higher IgG epitope diversity to HDM allergens compared to placebo-treated individuals at 24 months of treatment (P < 0.05), while no increase in IgE diversity was seen. At 24 months of treatment, IgG4 diversity for HDM allergens was significantly higher in the pAIT-treated patients compared to placebo group (P < 0.05). Potentially beneficial changes in epitope recognition throughout the treatment are also seen in peptides derived from Der f proteome.
Conclusion: These data suggest a beneficial immunomodulation of preventive sublingual immunotherapy at a molecular level by favoring a broader blocking repertoire and inhibiting epitope spreading.
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| http://dx.doi.org/10.1111/all.13658 | DOI Listing |
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