A new meroterpenoid, named terretonin D1 (), and three known ones, terretonin (), terretonin A (), and terretonin D (), were isolated from marine-derived fungus ML-44. The structure of was elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and the absolute configuration was determined by X-ray crystallographic analysis. The anti-inflammation activity of - was preliminarily tested, and all of them weakly inhibited the nitric oxide (NO) production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS), with inhibitory rates of 22-34% at 50 μg/mL.
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