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Closed-Loop Therapy and Sleep in Young People Newly Diagnosed With T1D and Their Parents.
J Diabetes Sci Technol
October 2024
Department of Psychology, Royal Holloway, University of London, Egham, UK.
Background: A diagnosis of type 1 diabetes in a young person can create vulnerability for sleep. Historically it has been rare for young people to be offered a closed-loop system soon after diagnosis meaning that studies examining sleep under these circumstances in comparison with standard treatment have not been possible. In this study, we examine sleep in young people (and their parents) who were provided with hybrid closed-loop therapy at diagnosis of type 1 diabetes versus those who receive standard treatment over a 2-year period.
View Article and Find Full Text PDFPediatric MOG-Ab-Associated Encephalitis: Supporting Early Recognition and Treatment.
Neurol Neuroimmunol Neuroinflamm
December 2024
From the Department of Neurology (N.N.K., O.A.-M., Y.H.), Great Ormond Street Hospital for Children NHS Foundation Trust; Department of Neuroinflammation (N.N.K., D.C., O.A.-M., C.H., O.C., Y.H.), Institute of Neurology, University College London; Children's Neurosciences (M.E., V.L., M.L., T.R.), Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust; Department of Women and Children's Health (M.E., M.L., T.R.), School of Life Course Sciences (SoLCS), King's College London; Department of Paediatrics (A.S., S.R., J.P.), Children's Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust; Department of Paediatric Neurology (M.V.C.), Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust; Translational and Clinical Research Sir James Spence Institute (R.F.), University of Newcastle, Royal Victoria Infirmary; Department of Neurology (R.F.), Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust; Department of Neurology (R.K.), Alder Hey Children's Hospital, Alder Hey Children's NHS Foundation Trust, Liverpool; Department of Paediatric Neurology (D.R., Siobhan West), Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust; Department of Neurology (E.W., Sukhvir Wright), Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust; Department of Neuroradiology (A.B., K.M.), Great Ormond Street Hospital, Great Ormond Street Hospital Trust, London, United Kingdom; Department of Neurology (E.P.F.), Laboratory Medicine and Pathology and Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN; NIHR University College London Hospitals Biomedical Research Centre (O.C.); and Department of Neuroinflammation (O.C.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Article Synopsis
- A study assessed children under 18 with antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab), focusing on those with encephalitis who didn’t fit the criteria for acute disseminated encephalitis (ADEM), comparing them to those with ADEM.
- Out of 235 MOG-Ab positive patients, 33 had encephalitis and 74 had ADEM, with common symptoms including headache, seizures, and fever; 24% had a normal initial brain MRI.
- Findings indicated that children with encephalitis were generally older, more often admitted to intensive care, and had a delayed start of steroid treatment, suggesting MOG-Ab testing is essential for suspected encephalitis
Multimodal Outcomes of Early Open Extended Midline Strip Craniectomy With Bilateral Microbarrel Staving for Correction of Isolated Nonsyndromic Sagittal Synostosis.
J Craniofac Surg
October 2024
Department of Craniofacial Surgery, Alder Hey Children's Hospital NHS Trust, Eaton.
Aim: Sagittal synostosis is the most common craniosynostosis. The aim of surgery is to preserve cognitive function and to correct the morphologic changes. In our unit, the authors offer strip craniectomy and microbarrel staving (SMB) performed at 16 to 22 weeks.
View Article and Find Full Text PDFPharmacovigilance in the Age of Legalized Cannabis: Using Social Media to Monitor Drug-Drug Interactions Between Immunosuppressants and Cannabis-Derived Products.
Drug Saf
September 2024
Altman Clinical and Translational Research Institute, University of California San Diego, #333 CRSF 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Introduction: A clinical trial of Epidiolex, the only US FDA-approved cannabis-derived consumer product (CDP), discovered an interaction with an immunosuppressant (tacrolimus) that led to drug toxicity, highlighting the unique intersection of prescription and commonly unregulated consumer products.
Objective: We aimed to identify if similar drug-drug interactions (DDIs) are occurring among the consumer CDP market, even though they cannot be identified through trials.
Methods: We searched Reddit for subreddits related to CDPs or health, resulting in 63,561,233 posts.
Dual diagnosis of achondroplasia and mandibulofacial dysostosis with microcephaly.
BMC Med Genomics
September 2024
Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
Article Synopsis
- The case study discusses a female patient diagnosed with achondroplasia due to an FGFR3 gene variant, but her symptoms indicated a more complex condition, prompting further genetic analysis.* -
- Despite her initial diagnosis, the patient exhibited unusual features such as small head size, distinct facial characteristics, speech delay, and hearing loss, leading to her participation in extensive genetic research efforts.* -
- Ultimately, the discovery of an EFTUD2 gene rearrangement revealed a second diagnosis of mandibulofacial dysostosis with microcephaly, marking a rare instance of dual genetic disorders in one individual and emphasizing the need for careful genetic evaluations.*
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