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IL-33 Reduces Saturated Fatty Acid Accumulation in Mouse Atherosclerotic Foci.
Nutrients
April 2024
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Article Synopsis
- - The study investigates the unclear mechanisms of atherosclerosis, focusing on the role of type 2 innate lymphocytes (ILC2), which have anti-inflammatory effects and could protect against the disease.
- - Researchers used two types of mice—ApoE KO and ApoEST2 DKO—subjected to a high-fat, high-sucrose diet to observe differences in atherosclerosis development, finding that ApoEST2 DKO mice exhibited worsened atherosclerosis due to reduced ILC2.
- - Treatments with saturated fatty acids and IL-33 on human aortic endothelial cells showed that IL-33 may help prevent fatty acid accumulation in atherosclerotic areas, indicating its potential protective role in atherosclerosis
Impact of TNF and IL-33 Cytokines on Mast Cells in Neuroinflammation.
Int J Mol Sci
March 2024
Section of Legal Medicine, Department of Medicine and Aging Sciences, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Mast cells (MCs) are derived from hematopoietic progenitors, mature in vascularized tissues, and participate in innate and acquired immunity. Neuroinflammation is a highly debated topic in the biomedical literature; however, the impact of tumor necrosis factor (TNF) and IL-33 on MCs in the brain has not been widely addressed. MCs can be activated by IgE binding to FcεRI, as well as by different antigens.
View Article and Find Full Text PDFGlyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice.
J Neuroinflammation
November 2023
Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Background: Lipid metabolism has a crucial role in neural repair in neurodegenerative diseases. We recently revealed that lipogenesis-mediated interleukin-33 (IL-33) upregulation lead to blood-brain barrier (BBB) repair after ischemic stroke. However, manipulating the key enzyme fatty acid synthase (FASN) to enhance lipogenesis was very challenging.
View Article and Find Full Text PDFGlucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.
J Immunol
December 2023
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
Article Synopsis
- Platelets play a significant role in allergic asthma and aspirin-exacerbated respiratory disease (AERD) by being activated and influencing inflammatory responses.
- The study found that the GLP-1 receptor (GLP-1R) agonist liraglutide reduced platelet activation and airway resistance in a mouse model of AERD, indicating its potential therapeutic benefits.
- Liraglutide showed promise in inhibiting platelet activation in both mice and human patients with AERD, suggesting that targeting the GLP-1R could be a new strategy for managing asthma-related inflammation.
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin.
J Eur Acad Dermatol Venereol
February 2024
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Background: Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD.
Methods: Twenty-five Inuit children with AD and 25 Inuit control children were clinically examined and compared to previously collected data from 25 Danish children with AD.
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