The original version of this article contained a mistake in the figure. The Ca2 + confocal image for the 2-APB/Apicidin-120 min in Fig. 5d is incorrect. The correction does not influence either the validity of the published data or the conclusion described in the article. The corrected Fig. 5d is given below.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s10495-018-1492-5 | DOI Listing |
Pak J Med Sci
January 2023
Kalamegam Gauthaman, MBBS, PhD Professor, Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental, College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Background & Objectives: Accurate identification of molecular and toxicological functions of potential drug candidates is crucial for drug discovery and development. This may aid in the evaluation of the risks of genotoxicity and carcinogenesis. In addition, in silico characterization of existing and new drugs might offer clues for future investigations and aid in the development of anticancer treatments.
View Article and Find Full Text PDFApoptosis
February 2019
Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 130-701, Republic of Korea.
The original version of this article contained a mistake in the figure. The Ca2 + confocal image for the 2-APB/Apicidin-120 min in Fig. 5d is incorrect.
View Article and Find Full Text PDFJ Toxicol Environ Health A
December 2005
College of Pharmacy, Sungkyunkwan University, Changan-gu, Suwon, Kyonggi-do, Korea.
Apicidin is a potent histone deacetylase inhibitor exhibiting broad-spectrum antiprotozoal, antiproliferative, and antiangiogenic activities. This study was conducted to calculate the intrinsic hepatic clearance of apicidin in mouse, rat, and human. The microsomal stability was determined in pooled microsomes of mouse, rat, and human.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!