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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: models/Detail_model.php
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Function: strpos
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Function: insertAPISummary
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Filename: controllers/Detail.php
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This paper presents Neutron Capture Enhanced Particle Therapy (NCEPT), a method for enhancing the radiation dose delivered to a tumour relative to surrounding healthy tissues during proton and carbon ion therapy by capturing thermal neutrons produced inside the treatment volume during irradiation. NCEPT utilises extant and in-development boron-10 and gadolinium-157-based drugs from the related field of neutron capture therapy. Using Monte Carlo simulations, we demonstrate that a typical proton or carbon ion therapy treatment plan generates an approximately uniform thermal neutron field within the target volume, centred around the beam path. The tissue concentrations of neutron capture agents required to obtain an arbitrary 10% increase in biological effective dose are estimated for realistic treatment plans, and compared to concentrations previously reported in the literature. We conclude that the proposed method is theoretically feasible, and can provide a worthwhile improvement in the dose delivered to the tumour relative to healthy tissue with readily achievable concentrations of neutron capture enhancement drugs.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215016 | PMC |
http://dx.doi.org/10.1038/s41598-018-34643-w | DOI Listing |
Front Cell Neurosci
December 2024
Department of Molecular Biosciences, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Introduction And Methods: Aiming to evaluate safety aspects of a recently proposed approach to target Alzheimer's disease, we mimicked a complex boron neutron capture therapy field using a mixed beam consisting of high- and low-linear energy transfer (LET) radiation, Am alpha particles (α) and/or X-ray radiation respectively, in human microglial (HMC3) cells.
Results: Acute exposure to 2 Gy X-rays induced the strongest response in the formation of γH2AX foci 30 min post irradiation, while α- and mixed beam-induced damage (α:X-ray = 3:1) sustained longer. Fractionation of the same total dose (0.
Appl Radiat Isot
December 2024
Division of Quantum and Radiation Engineering, Graduate School of Engineering, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8570, Japan.
A novel anticoincidence detector is proposed for the measurement of 478 keV gamma radiation for evaluation of boron neutron capture therapy. The Compton continuum around the target photopeak position is effectively suppressed by measuring only the Compton gamma rays scattered at small angles from the primary detector. A numerical evaluation using Monte Carlo simulations estimated an 80% reduction in counts, and the developed prototype detector showed 4% suppression of the Compton continuum of cobalt-60 gamma rays.
View Article and Find Full Text PDFACS Med Chem Lett
December 2024
School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
This research investigates boronated tryptophans as potential boron delivery agents for boron neutron capture therapy (BNCT) of cancer. We synthesized both enantiomers of 5- and 6-boronotryptophans ( and ) using simple and inexpensive methods. Their uptake was assessed in two human cancer cell lines, CAL27 (head and neck cancer) and U87-MG (brain cancer), and compared to l--boronophenylalanine (l-BPA) as a reference.
View Article and Find Full Text PDFMed Res Rev
December 2024
Sunshine Lake Pharma Co. Ltd., Dongguan, China.
Targeted charged alpha- and beta-particle therapies are currently being used in clinical radiation treatments as newly developed methods for either killing or controlling tumor cell growth. The alpha particles can be generated either through a nuclear decay reaction or in situ by a nuclear fission reaction such as the boron neutron capture reaction. Different strategies have been employed to improve the selectivity and delivery of radiation dose to tumor cells based on the source of the clinically used alpha particles.
View Article and Find Full Text PDFJ Mater Chem A Mater
December 2024
Empa, Swiss Federal Laboratories for Materials Science and Technology Dübendorf 8600 Switzerland
Battery research often encounters the challenge of determining chemical information, such as composition and elemental oxidation states, of a layer buried within a cell stack in a non-destructive manner. Spectroscopic techniques based on X-ray emission or absorption are well-suited and commonly employed to reveal this information. However, the attenuation of X-rays as they travel through matter creates a challenge when trying to analyze layers buried at depths exceeding hundred micrometers from the sample's surface.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!