A sweet alternative: maintaining M2 macrophage polarization.

Sci Immunol

Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplantation, Batchelor Children's Research Institute, Department of Microbiology & Immunology, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Holtz Children's Hospital, Miller School of Medicine, University of Miami, Miami, FL, USA.

Published: November 2018

Glycolytic metabolism serves as an alternative energy source for M2 macrophages when their usual energy production method, oxidative phosphorylation, fails.
This backup system ensures that M2 macrophages can still carry out their functions, even under compromised conditions.
Understanding this metabolic flexibility is important for studying immune responses and potential therapeutic interventions.

Glycolytic metabolism functions as a backup mechanism for M2 macrophage polarization when oxidative phosphorylation is disrupted.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861128	PMC
http://dx.doi.org/10.1126/sciimmunol.aav7759	DOI Listing

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