How amyloid‐β (Aβ) and tau exacerbate Alzheimer's disease (AD) at a subcellular level is only incompletely understood. Norambuena (2018) report crosstalk between mitochondria and lysosomes and identify a role for lysosomal mTORC1 in the nutrient‐induced activation of mitochondria. This lysosomal signalling pathway is strongly inhibited by oligomeric Aβ through the tau‐dependent activation of plasma membrane‐localized mTORC1. Together, these results identify a further role for tau in mediating Aβ toxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236328 | PMC |
| http://dx.doi.org/10.15252/embj.2018100839 | DOI Listing |
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