Chemical investigation on CHCl extract of the marine sponge , collected from the South China Sea, afforded two new 5,6-epoxysterols, 5α,6α-epoxycholesta-8(14),22()-diene-3,7-diol () and (24)-24-ethyl-5α,6α-epoxycholesta-8(14),22()-diene-3,7-diol () along with ten known related steroid analogs (-). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparison with the literature. All isolates were tested for cytotoxicity against three tumor cell lines only known compounds and exhibited notable cytotoxic activity against A549 (IC: 3.0 and 5.6 μM), PC9 (2.0 and 15.6 μM), and MCF-7 (9.4 and 11.8 μM) cell lines, respectively.
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