AI Article Synopsis
Article Abstract
Subgroup C Avian Metapneumoviruses (AMPV-C) has two lineages, one mostly in turkeys and one mostly in ducks. To investigate the molecular basis of AMPV-C host tropism, a reverse genetics system for a duck AMPV-C virus was developed. A recombinant copy and a recombinant virus in which the SH protein had been exchanged for that of a turkey AMPV-C were rescued. No change in cytopathogenic effect or replication profile in vitro were observed for either virus compared to the wild type. In SPF Muscovy ducks the wild type and its recombinant copy were equally pathogenic. Exchanging the SH in the recombinant copy produced the same results. In SPF turkeys, neither recombinant virus was pathogenic, although both showed a low level of replication. Thus, from the current model, it appears that AMPV-C SH proteins derived from the different species are compatible and that turkey SH does not affect duck AMPV-C pathogenicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.virol.2018.10.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Isolation and characterization of an avian metapneumovirus subtype C circulating in Cherry Valley ducks.
Poult Sci
December 2024
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Tai'an 271017, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai'an 271017, China. Electronic address:
Since 2023, an infectious upper respiratory tract disease has been persisted in outbreaks among in a flock of Cherry Valley ducks in Shandong Province, China. This outbreak was traced to avian metapneumovirus subtype C (aMPV-C), a significant pathogen associated with egg-drop and acute respiratory diseases in poultry. It is noteworthy that prior to this, aMPV-C infection had not been previously documented in Cherry Valley ducks within China.
View Article and Find Full Text PDFCharacterization of avain metapneumovirus subgroup C isolated from chickens in Beijing, China.
Poult Sci
January 2023
College of Veterinary Medicine, Yangzhou University, Yangzhou, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China. Electronic address:
Avian metapneumovirus (aMPV) is an important causative agent that causes acute respiratory disease and egg-dropping in chickens and turkeys. Here, we characterized an aMPV subgroup C (aMPV/C) from 320-day-old broiler breeder chickens with severe respiratory diseases in Beijing, China, as evidenced by RT-PCR typing and confirmation of the nucleoprotein (N) gene sequence. The N gene sequence of the aMPV/C strain (designated BJ17) exhibited no deletions or insertions and possessed 94.
View Article and Find Full Text PDFMolecular characterization of avian metapneumovirus subtype C detected in wild mallards (Anas platyrhynchos) in The Netherlands.
Transbound Emerg Dis
November 2022
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Hannover, Germany.
Avian metapneumovirus (AMPV) represents a long-term threat to the poultry industry due to its etiological role in the induction of acute respiratory disease and/or egg drop syndrome in domestic turkeys, chickens, and ducks. Although this disease is commonly referred to as turkey rhinotracheitis, the host range of AMPV encompasses many avian species. We have screened 1323 oropharyngeal- and cloacal swab samples obtained from wild mallards in the Netherlands from 2017 to 2019 by RT-PCR using a degenerate primer pair to detect all members of the Paramyxoviridae and Pneumoviridae or an avian metapneumovirus subtype C (AMPV-C)-specific RT-qPCR assay.
View Article and Find Full Text PDFFirst detection of avian metapneumovirus subtype C Eurasian lineage in a Eurasian wigeon () wintering in Northeastern Italy: an additional hint on the role of migrating birds in the viral epidemiology.
Avian Pathol
June 2022
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Avian metapneumovirus (aMPV) economically affects the global poultry industry causing respiratory and reproductive disorders. Considering the paucity of data on aMPV occurrence in European free-ranging avifauna, a molecular survey was conducted on wild birds of 23 species belonging to the orders Anseriformes, Charadriiformes or Passeriformes, captured alive and sampled in Northeast Italy as part of the national avian influenza virus (AIV) surveillance activities. A total of 492 oropharyngeal swabs, collected from 2007-2010, all AIV-negative, were screened from aMPV by subtype-specific qRT-PCR.
View Article and Find Full Text PDFResearch Note: Detection of Avian metapneumovirus subgroup C specific antibodies in a mallard flock in Italy.
Poult Sci
July 2021
VIPAC Unit, Anses (French Agency for Food, Environmental and Occupational Health Safety), Ploufragan-Plouzané-Niort Laboratory, B.P.53, Ploufragan 22440, France.
Avian metapneumovirus (aMPV) is a viral pathogen that causes respiratory signs and drops in egg production most notably in turkeys but also affects chickens, ducks and other species. Four subgroups (aMPV-A, -B, -C and -D) have been characterized to date, which differ genetically, antigenically and in terms of geographic distribution and host range. Despite the rising awareness towards aMPV, many aspects of its epidemiology are still poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!