AI Article Synopsis
- Ying et al. (2018) discovered that MLKL plays a new role in helping sciatic nerve regeneration following injury.
- This process involves destabilization of the myelin sheath, a protective layer around nerve fibers.
- Importantly, this function does not depend on necroptosis (a type of cell death) and requires a specific phosphorylation at the MLKL-S441 site.
Article Abstract
In this issue of Molecular Cell, Ying et al. (2018) report on a novel function of MLKL in sciatic nerve regeneration after injury through myelin sheath destabilization. This function of MLKL is independent of necroptosis execution and requires phosphorylation at MLKL-S441.
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| http://dx.doi.org/10.1016/j.molcel.2018.10.025 | DOI Listing |
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