Intra-slice motion correction is an important step for analyzing volume variations and pathological formations from intravascular imaging. Optical coherence tomography (OCT) has been recently introduced for intravascular imaging and assessment of coronary artery disease. Two-dimensional (2-D) cross-sectional OCT images of coronary arteries play a crucial role to characterize the internal structure of the tissues. Adjacent images could be compounded; however, they might not fully match due to motion, which is a major hurdle for analyzing longitudinally each tissue in 3-D. The aim of this study is to develop a robust tissue-matching-based motion correction approach from a sequence of 2-D intracoronary OCT images. Our motion correction technique is based on the correlation between deep features obtained from a convolutional neural network (CNN) for each frame of a sequence. The optimal transformation of each frame is obtained by maximizing the similarity between the tissues of reference and moving frames. The results show a good alignment of the tissues after applying CNN features and determining the transformation parameters.
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http://dx.doi.org/10.1109/JBHI.2018.2878914 | DOI Listing |
Biophys J
January 2025
Department of Physics and Astronomy, Department of Chemistry, NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, California, USA. Electronic address:
In this work we present a minimal structure-based model of protein diffusional search along local DNA amid protein binding and unbinding events on the DNA, taking into account protein-DNA electrostatic interactions and hydrogen-bonding (HB) interactions or contacts at the interface. We accordingly constructed the protein diffusion-association/dissociation free energy surface and mapped it to 1D as the protein slides along DNA, maintaining the protein-DNA interfacial HB contacts that presumably dictate the DNA sequence information detection. Upon DNA helical path correction, the protein 1D diffusion rates along local DNA can be physically derived to be consistent with experimental measurements.
View Article and Find Full Text PDFBiomed Opt Express
January 2025
Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
The motion of the trabecular meshwork (TM) facilitates the aqueous drainage from the anterior chamber to the venous system, thereby maintaining normal intraocular pressure. As such, characterizing the TM motion is valuable for assessing the functionality of the aqueous outflow system, as demonstrated by previous phase-sensitive optical coherence tomography (OCT) studies. Current methods typically acquire motion from a single cross-sectional plane along the circumference of the anterior chamber.
View Article and Find Full Text PDFMagn Reson Med
January 2025
Department of Radiology, Stanford University, Stanford, California, USA.
Purpose: To provide a fast quantitative imaging approach for a 0.55T scanner, where signal-to-noise ratio is limited by the field strength and k-space sampling speed is limited by a lower specification gradient system.
Methods: We adapted the three-dimensional spiral projection imaging MR fingerprinting approach to 0.
Nat Commun
January 2025
Chemical Biology I, Groningen Biomolecular Sciences & Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands.
Transl Vis Sci Technol
January 2025
New England Eye Center, Tufts Medical Center, Boston, MA, USA.
Purpose: To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.
Methods: In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution).
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