Possible protective effect of platelet-rich plasma on a model of cisplatin-induced nephrotoxicity in rats: A light and transmission electron microscopic study.

Background: Cisplatin (Cis), is a potent chemotherapeutic drug. However, Cis nephrotoxicity is high, thus limiting its use. Platelet-rich plasma (PRP) is an autologous product, easy to get from blood centrifugation. The aim of this study is to investigate the effects of PRP in reversing Cis-induced nephrotoxicity.

Materials And Methods: Thirty-two adult albino rats were distributed into Group I, the control group; Group II, in which the rats received Cis (5 mg·kg ·day , intraperitoneal); Group III and Group IV, in which the rats received Cis, followed by normal saline and PRP distribution, respectively (1 ml) over the renal surface 24 hr later. All rats were killed on the eighth day of the experiment. Histopathological changes were examined.

Results: Glomerular atrophy, tubular degeneration, interrupted PAS reaction, highly expressed caspase-3, and ultra-structural changes were observed after Cis injection, which improved with PRP administration.

Conclusion: PRP reduced acute kidney injury through the epithelial GFs.