A convenient stereospecific synthesis of 6'-fluoro-3-deazaneplanocin (6) has been accomplished from d-ribose in 15 steps. It is reported to possess significant activity towards Ebola (Zaire, Vero, μM: EC < 0.36; CC 125; SI > 347) with moderate inhibition of the target enzyme (S-adenosylhomocysteine hydrolase), which did not correlate directly with its anti-Ebola effects. Compound 6, with limited cytotoxicity, also displayed activity against measles, H1N1 and Pichinde.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2018.10.030 | DOI Listing |
Publication Analysis
Top Keywords
6'-fluoro-3-deazaneplanocin synthesis
4
synthesis antiviral
4
antiviral properties
4
properties including
4
including ebola
4
ebola convenient
4
convenient stereospecific
4
stereospecific synthesis
4
synthesis 6'-fluoro-3-deazaneplanocin
4
6'-fluoro-3-deazaneplanocin accomplished
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!