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Contributions of Hope in physical activity and exercise goal attainment in college students.
Front Psychol
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Indiana University Indianapolis, School of Health and Human Sciences, Indianapolis, IN, United States.
Background: College students significantly decrease physical activity (PA) over the course of a four-year degree, increasing the risk for chronic disease. Research shows that psychological constructs impact behavior and goal attainment. However, little is known regarding the effect of psychological variables on PA levels in students.
View Article and Find Full Text PDFGeneration and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes.
Front Immunol
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Laboratory of Molecular Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on the surface of activated T cells. Upon interaction with its cognate ligand, OX40L, OX40 transmits costimulatory signals to antigen-primed T cells, promoting their activation, differentiation, and survivalprocesses essential for the establishment of adaptive immunity. Although the OX40-OX40L interaction has been extensively studied in the context of disease treatment, developing a substitute for the naturally expressed membrane-bound OX40L, particularly a multimerized OX40L trimers, that effectively regulates OX40-driven T cell responses remains a significant challenge.
View Article and Find Full Text PDFExploring mosquito virome dynamics within São Paulo Zoo: insights into mosquito-virus-environment interactions.
Front Cell Infect Microbiol
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Institute of Biological Sciences, Federal University of Pará, Belem, Pará, Brazil.
Background: Mosquito-borne diseases have a significant public health threat worldwide, with arboviruses accounting for a high proportion of infectious diseases and mortality annually. Brazil, in particular, has been suffering outbreaks of diseases transmitted by mosquito viruses, notably those of the genus, such as dengue, Zika, and chikungunya. Against this background, the São Paulo Zoo is an intriguing ecological niche to explore the virome of mosquitoes, potentially shedding light on the dynamics of arbovirus transmission within a confined setting.
View Article and Find Full Text PDFProtective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion.
World J Stem Cells
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Internal Medicine-II, Paracelsus Medical University Salzburg, Salzburg 5020, Austria.
Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and reducing cardiovascular mortality. Extracellular vesicles (EVs) derived by adipose mesenchymal stem cells may mediate the paracrine effects of stem cells and provide regenerative and anti-inflammatory properties, which are enhanced by γ-aminobutyric acid. The protective effects on cardiac myocytes may result from the EV embarked by miR-21-5p, which is a target for thioredoxin-interacting protein, regulating the formation of thioredoxin-interacting protein-thioredoxin complexes and subsequently enhancing the antioxidant activity of thioredoxin.
View Article and Find Full Text PDFEditorial: Digging deeper: understanding root-pathogen interactions.
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Molecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
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