Saline Infusion Sonography Can Improve Outcome in Subsequent ICSI Cycles When No Intrauterine Pathology Is Detected.

Objective: To analyze the benefits of saline infusion sonography (SIS).due to its endometrial injury effect on outcomes of subsequent intracytoplasmic sperm injection (ICSI) cycles.

Study Design: This study is a retrospective anal- ysis of 398 patients under- going ICSI cycles. The bio- chemical and clinical preg- nancy rates of 45 patients who underwent SIS prior to starting an ICSI cycle were compared to those of controls.

Results: Endometrial thickness was significantly higher in patients who underwent SIS (p=0.016). The biochemical pregnancy rate was statistically significant- ly higher in the SIS group than in the control group (p=0.040). The clinical pregnancy rate was 55.56% in patients who underwent SIS, while it was only 39.09% in the control group. The difference was statistically sig- nificant (p=0.037).

Conclusion: .SIS can be used to assess the endome- trial cavity prior to ICSI cycle; moreover, SIS might be associated with improved outcomes when no intrauterine pathology is detected. Confirmation of this finding via future robust randomized trials is needed and would be useful to further guide clinical practice.