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Interplay Between Helicobacter pylori Infection, Interleukin-11, and Leukemia Inhibitory Factor in Gastric Cancer Among Egyptian Patients. | LitMetric

AI Article Synopsis

  • Helicobacter pylori is a common Gram-negative bacterium linked to gastric inflammation and is a significant risk factor for gastric cancer (GC).
  • A study on 147 patients found higher levels of interleukin-11 (IL-11) and leukemia inhibitory factor (LIF) in those with GC compared to those with gastritis, indicating a strong association with H. pylori infection.
  • The findings suggest a potential connection between immune responses to H. pylori and its role in gastric diseases, highlighting the need for targeted immunotherapy strategies against cytokines related to H. pylori.

Article Abstract

Helicobacter pylori is a ubiquitous Gram-negative bacterium, that is responsible for gastric mucosal inflammation. It is the most common risk factor for gastric cancer (GC). The current study aimed to investigate the association between interleukin-11 (IL-11) and leukemia inhibitory factor (LIF) levels among H. pylori-infected Egyptian patients with gastritis and GC. One hundred forty-seven patients with gastric lesions were endoscopically biopsied and assessed using rapid urease test and immunohistochemistry. Quantitative real-time polymerase chain reaction was done for the detection of H. pylori load in gastric biopsies and detection of LIF as well as IL-11 relative gene expression. The mean values of H. pylori load, LIF, and IL-11 were significantly elevated in GC patients compared to gastritis group (P < 0.0001). A positive significant correlation was detected between mucosal levels of LIF, IL-11, and H. pylori load in both groups. Both LIF and IL-11 had the same pattern of expression in gastric tissues with different types of gastritis and different types and grades of gastric carcinoma. This report could clarify the molecular events associated with the immune response against H. pylori infection and H. pylori-associated pathology. Therefore, development of immunotherapy strategies against H. pylori-induced cytokines becomes inevitable.

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Source
http://dx.doi.org/10.1089/jir.2018.0065DOI Listing

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