Rapid Detection of Fosfomycin Resistance in Escherichia coli.

J Clin Microbiol

Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Published: January 2019

The rapid fosfomycin/ NP test was developed to detect fosfomycin resistance in isolates. The test is based on glucose metabolization and the detection of bacterial growth in the presence of fosfomycin at 40 µg/ml. Bacterial growth is visually detectable by an orange-to-yellow color change of red phenol, a pH indicator. A total of 100 isolates, among which 22 were fosfomycin resistant, were used to evaluate the test performance. The sensitivity and specificity of the test were 100% and 98.7%, respectively. This new test is user friendly, sensitive and specific, and its results are obtained in 1 h 30 min.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322471PMC
http://dx.doi.org/10.1128/JCM.01531-18DOI Listing

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