AI Article Synopsis
- Venom peptides have potential as new drug sources but the current identification process is labor-intensive and costly, often failing to yield successful pharmaceuticals.
- These peptides can modulate ion channels and receptors, making them valuable for targeting diseases and offering a unique avenue for drug discovery.
- The review will discuss advancements in technology, such as microfluidic biosensing systems and fluorescence detection methods, that improve the screening process for venom peptides in drug development.
Article Abstract
Background: Venom peptides are a proven resource for identifying novel drugs, however the process of identifying bioactive venom peptides is currently labor intensive, costly, and rarely results in pharmaceutical success. As venom peptides are modulators of ion channels and receptors their potential for manipulating cell signals in diseased states are unique and offer an untapped resource for finding new medicines. Recent advances in -omic technologies, and microfluidic biosensing systems have transformed how venom peptides are discovered and characterized.
Conclusion: This review will cover past, present and future approaches for screening venom peptides for drug discovery and development. Specifically, we will highlight online high-resolution microfluidic biosensing systems and new fluorescence detection methods that can be adapted to expand the discovery and characterization of venom peptide drugs.
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| http://dx.doi.org/10.2174/0929866525666181101103047 | DOI Listing |
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