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Exposure to toxins causes lasting damaging effects on the body. Numerous studies in humans and animals suggest that diet has the potential to modify the epigenome and these modifications can be inherited transgenerationally, but few studies investigate how diet can protect against negative effects of toxins. Potential evidence in the primary literature supports that caloric restriction, high-fat diets, high protein-to-carbohydrate ratios, and dietary supplementation protect against environmental toxins and strengthen these effects on their offspring's epigenome.
View Article and Find Full Text PDFFactors influencing evidence-based cardiovascular disease prevention programming in rural African American communities: a community-engaged concept mapping study.
Implement Sci Commun
January 2025
Center for Health Equity Research, School of Medicine, University of North Carolina at Chapel Hill, 333 South Columbia Street, MacNider Hall Ste 323, Chapel Hill, NC, 27599, USA.
Background: African Americans experience cardiovascular disease (CVD) disparities, and the burden is greatest in the rural south. Although evidence-based CVD prevention and management programs have been tailored to this context, implementation has been limited and not sustained long-term. To understand how to implement and sustain evidence-based CVD programs at scale, we must explore the perspectives of organizations serving rural African American communities and situate findings within foundational Implementation Science frameworks.
View Article and Find Full Text PDFChallenges and opportunities for digital twins in precision medicine from a complex systems perspective.
NPJ Digit Med
January 2025
Department of Physics and Astronomy "Galileo Galilei", University of Padua, Padova, Italy.
Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations that produce behavior based on explicitly defined biological hypotheses and multiscale mechanisms is beneficial. It enables the exploration of diverse therapeutic strategies and supports dynamic clinical decision-making through insights from network science, quantitative biology, and digital medicine.
View Article and Find Full Text PDF[Exploring the voice of patients: Mapping their experience following care in an integrated health area].
J Healthc Qual Res
January 2025
Unidad de Calidad Asistencial, Área 1 Murcia-Oeste. Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, España.
Background And Aim: Measuring patient-reported experience measures (PREMs) is essential for the continuous improvement of quality. This study aims to assess the quality perceived by patients in the key care processes of an integrated health area measuring PREM elements, with the goal of identifying opportunities for improvement.
Methods: The research was conducted in the first half of 2023 within a Spanish integrated health area, analysing five key healthcare processes: Primary Care, Emergency Services, Hospitalisation, Consultations, and Surgery.
Urgent findings in CT chest examinations: Radiography and medical students' capabilities and learning perspectives - a preliminary study.
Radiography (Lond)
January 2025
Discipline of Medical Imaging Science, University of Sydney, Camperdown, NSW, Australia. Electronic address:
Introduction: Radiography and medical students (RMS), upon graduation, require capabilities to provide life-saving care through identification and communication of urgent findings on radiological imaging. This preliminary study investigated RMS' ability to identify and categorise urgent findings on CT examinations. It also explored their experiences of image interpretation education.
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