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Case-area targeted interventions and free chlorine residual in household drinking water: An observational cohort study during a cholera outbreak in Northeast Nigeria.
PLoS Negl Trop Dis
January 2025
Center for Humanitarian Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Background: Cholera outbreaks are surging worldwide. Growing research supports case-area targeted interventions (CATIs), whereby teams provide a package of interventions to case and neighboring households, as an effective strategy in cholera outbreak control, particularly in humanitarian settings. While research exists on individual CATI interventions, research gaps exist on outcomes of integrated interventions during CATI responses.
View Article and Find Full Text PDFγ-secretase facilitates retromer-mediated retrograde transport.
J Cell Sci
January 2025
Department of Genetics, Yale School of Medicine, USA.
Retromer mediates retrograde transport of protein cargos from endosomes to the trans-Golgi network (TGN). γ-secretase is a protease that cleaves the transmembrane domain of its target proteins. Although retromer can form a stable complex with γ-secretase, the functional consequences of this interaction are not known.
View Article and Find Full Text PDFGut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response.
Biomedicines
January 2025
Department of Biochemistry, Microbiology, and Immunology, Wayne State University, Detroit, MI 48201, USA.
Cholera is a diarrheal disease prevalent in populations without access to clean water. Cholera is caused by which colonizes the upper small intestine in humans once ingested. A growing number of studies suggest that the gut microbiome composition modulates animal behavior.
View Article and Find Full Text PDFMultistate cholera outbreak in Sudan amidst ongoing armed conflict, 2023-2024.
Int J Infect Dis
January 2025
Eastern Mediterranean Public Health Network.
In 2023, Sudan was affected by a major cholera outbreak affected 10 states amidst armed conflict that severely disrupted the health services. This study aimed to describe the magnitude, pattern, and trend (2023-2024) of cholera outbreak in Sudan across different states. Cholera outbreak caused significant morbidity and mortality facilitated the armed conflict that hampered the response by damaging infrastructure, displacing people, and disrupting healthcare services.
View Article and Find Full Text PDFTargeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines.
Hum Vaccin Immunother
December 2025
TIMM Laboratory, Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
The dissemination of tumor cells with ensuing metastasis is responsible for most cancer-related deaths. Cancer vaccines may, by inducing tumor-specific effector T cells, offer a strategy to eliminate metastasizing tumor cells. However, several obstacles remain in the development of effective cancer vaccines, including the identification of adjuvants that enhance the evolvement and efficacy of tumor-specific T cells.
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