Designing experiments and applying the process of science are core competencies for many introductory courses and course-based undergraduate research experiences (CUREs). However, experimental design is a complex process that challenges many introductory students. We describe the development of a tool to assess interrelated experimental design (TIED) in an introductory biology lab course. We describe the interrater reliability of the tool, its effectiveness in detecting variability and growth in experimental-design skills, and its adaptability for use in various contexts. The final tool contained five components, each with multiple criteria in the form of a checklist such that a high-quality response-in which students align the different components of their experimental design-satisfies all criteria. The tool showed excellent interrater reliability and captured the full range of introductory-student skill levels, with few students hitting the assessment ceiling or floor. The scoring tool detected growth in student skills from the beginning to the end of the semester, with significant differences between pre- and post-assessment scores for the Total Score and for the Data Collection and Observations component scores. This authentic assessment task and scoring tool provide meaningful feedback to instructors about the strengths, gaps, and growth in introductory students' experimental-design skills and can be scored reliably by multiple instructors. The TIED can also be adapted to a number of experimental-design prompts and learning objectives, and therefore can be useful for a variety of introductory courses and CUREs.
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http://dx.doi.org/10.1128/jmbe.v19i3.1627 | DOI Listing |
Expert Opin Drug Deliv
January 2025
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Introduction: Although there are numerous options for epilepsy treatment, its effective control continues unsatisfactory. Thus, search for alternative therapeutic options to improve the efficacy/safety binomial of drugs becomes very attractive to investigate. In this context, intranasal administration of antiseizure drugs formulated on state-of-the-art nanosystems can be a promising strategy.
View Article and Find Full Text PDFPaediatr Drugs
January 2025
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Background: This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in pediatric patients.
Methods: We searched PubMed, Embase, Cochrane Library, ClinicalTrials.gov, and the European Union Clinical Trials Register for English-language records from the establishment of the database up to October 17, 2023.
Jpn J Ophthalmol
January 2025
Institute for Photon Science and Technology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Purpose: There is no established method for visualizing the three-dimensional (3D) structure of the aqueous humor outflow tract. This study attempted to visualize the 3D structures of porcine and human ocular tissues, particularly the aqueous humor outflow tract using a transparency reagent composed of 2, 2-thiodiethanol.
Study Design: Clinical and experimental.
Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
View Article and Find Full Text PDFClin Rheumatol
January 2025
Department of Rheumatology and Immunology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Objectives: To investigate the clinical and laboratory features of Sjögren's syndrome-associated autoimmune liver disease (SS-ALD) patients and identify potential risk and prognostic factors.
Methods: SS patients with or without ALD, who visited Tongji Hospital between the years 2011 and 2021 and met the 2012 American College of Rheumatology (ACR) classification criteria for Sjögren's syndrome, were retrospectively enrolled. The clinical and laboratory data of the enrolled patients, including autoimmune antibodies, were collected and analyzed with principal component analysis, correlation analysis, LASSO regression, and Cox regression.
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