AI Article Synopsis
- Brain organoids are 3D structures resembling the developing human brain, made up of many cells that mimic its organization.
- They've been used to study genetic factors in neurodevelopmental disorders like microcephaly and autism, as well as the brain's response to environmental influences like the Zika virus.
- There's a need to explore how mature these organoids can become and their ability to process information, potentially leading to better models for understanding human brain development and personalizing treatments for neurological disorders.
Article Abstract
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to elucidate the genetic basis of certain neurodevelopmental disorders, such as microcephaly and autism; and to investigate the impact of environmental factors to the brain, such as during Zika virus infection. It remains to be explored how far brain organoids can functionally mature and process external information. An improved brain organoid model might reproduce important aspects of the human brain in a more reproducible and high-throughput fashion. This novel and complementary approach in the neuroscience toolbox opens perspectives to understand the fundamental features of the human neurodevelopment, with implications to personalize therapeutic opportunities for neurological disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289846 | PMC |
| http://dx.doi.org/10.1016/j.molmed.2018.09.005 | DOI Listing |
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