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| http://dx.doi.org/10.1111/dar.12846 | DOI Listing |
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Measuring Residents' Competence in Chest Tube Insertion on Thiel-Embalmed Bodies: A Validity Study.
Simul Healthc
December 2024
From the Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (L.D.M., I.V.H., L.D., W.W.); Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, Belgium (I.V.H., L.D.); Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (P.V.d.V.); Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium (P.V.d.V.); Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium (H.V., W.W.); Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (L.K.); and Copenhagen Academy for Medical Education and Simulation (CAMES), Copenhagen, Denmark (L.K.).
Introduction: Chest tube insertions (CTIs) have a high complication rate, prompting the training of technical skills in simulated settings. However, assessment tools require validity evidence prior to their implementation. This study aimed to collect validity evidence for assessment of technical skills in CTI on Thiel-embalmed human bodies.
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Biochemistry
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Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Janustatin A is a potently cytotoxic polyketide alkaloid produced at trace amounts by the marine bacterial plant symbiont . Its biosynthetic terminus features an unusual pyridine-containing bicyclic system of unclear origin, in which polyketide and amino acid extension units appear reversed compared to the order of enzymatic modules in the polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) assembly line. To elucidate unknown steps in heterocycle formation, we first established robust genome engineering tools in .
View Article and Find Full Text PDFTherapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways.
Cardiovasc Drugs Ther
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Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 226000, Jiangsu, China.
Purpose: Cardiac inflammation is a basic pathological process of diabetic cardiomyopathy (DCM). Inflammatory response is closely related to pyroptosis, which is a recently identified programmed cell death type. Curcumin (CUR) is a polyphenol extracted from turmeric and has been reported to be crucial in alleviating pyroptosis in DCM.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Alzheimer's Disease can present with heterogenous neurodegenerative patterns. In order to optimize clinical trials and personalized medicine, the identification and characterization of diverse pathological brain patterns associated with AD have become paramount. Optimal approaches to identify such heterogeneity are unknown.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.
Background: Deep Neural Networks (DNNs) have emerged as powerful tools in the biomedical field, particularly for the early detection of neurodegenerative diseases. Despite their complexity and data-intensive nature, simpler fully connected Convolutional Neural Network (SFCN) architectures have shown effectiveness in accurately discerning between subjects affected by Alzheimer's disease (AD) and healthy controls (HC). This model draws inspiration from the work of Peng H et al.
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