To find new higher fungicidal activities lead compounds and develop new eco-friendly agrochemicals, natural product phenazine-1-carboxylic acid (PCA) as scaffold, a series of 1,3,4-oxadiazol-2-yl thioether derivatives was synthesized and bio-assayed. The results reveal that most target compounds possessed moderate to good fungicidal activities against , and Compounds and exhibit more than 90% bioactivity against . The EC value of compounds and are 11.16 and 30.47 μM respectively, in particular, compound show equal activity against to PCA (10.49 μM). This result provides a valuable lead compound for further studies.
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