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Non-parametric Bayesian deep learning approach for whole-body low-dose PET reconstruction and uncertainty assessment.
Med Biol Eng Comput
January 2025
Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel.
Positron emission tomography (PET) imaging plays a pivotal role in oncology for the early detection of metastatic tumors and response to therapy assessment due to its high sensitivity compared to anatomical imaging modalities. The balance between image quality and radiation exposure is critical, as reducing the administered dose results in a lower signal-to-noise ratio (SNR) and information loss, which may significantly affect clinical diagnosis. Deep learning (DL) algorithms have recently made significant progress in low-dose (LD) PET reconstruction.
View Article and Find Full Text PDFCenter of mass acceleration during walking: comparison between IMU and camera-based motion capture methodologies.
Wearable Technol
November 2024
Department of Kinesiology, Iowa State University, Ames, IA, USA.
Placing an inertial measurement unit (IMU) at the 5th lumbar vertebra (L5) is a frequently employed method to assess the whole-body center of mass (CoM) motion during walking. However, such a fixed position approach does not account for instantaneous changes in body segment positions that change the CoM. Therefore, this study aimed to assess the congruence between CoM accelerations obtained from these two methods.
View Article and Find Full Text PDFEffects of Arthroscopic Surgery and Non-Surgical Therapy on Hip Contact Forces in Femoroacetabular Impingement Syndrome.
Med Sci Sports Exerc
December 2024
Griffith Centre of Biomedical and Rehabilitation Engineering (GCORE), Griffith University, Gold Coast, AUSTRALIA.
Introduction: We compared the 12-months effects of arthroscopic surgery and physiotherapist-led care for femoroacetabular impingement (FAI) syndrome on the time-varying magnitude of hip contact force and muscle contributions to hip contact force during walking.
Methods: Secondary analysis was performed on thirty-seven individuals with FAI syndrome who received biomechanical assessment before and 12-months following either arthroscopic surgery (n = 17) or physiotherapist-led care (Personalised Hip Therapy, PHT) (n = 20). At both time points, three-dimensional whole-body motions, ground reaction forces, and surface electromyograms (n = 14) were acquired during overground walking.
Upper body gait deviations in children with Duchenne muscular dystrophy.
Clin Biomech (Bristol)
December 2024
Department of Neuro-Orthopaedics, University of Basel Children's Hospital, Spitalstrasse 33, CH-4056 Basel, Switzerland. Electronic address:
Background: Duchenne muscular dystrophy is primarily a disease of progressive muscle degeneration affecting the whole body. It is important to preserve the patients' walking ability as long as possible. Inconclusive information on Duchenne muscular dystrophy gait pattern is available for the lower body and missing for the upper body.
View Article and Find Full Text PDFLocalized FDG loss in lung cancer lesions.
EJNMMI Res
November 2024
Dipartimento di Scienza Della Salute, Università Degli Studi di Genova, Genoa, Italy.
Background: Analysis of [18F]-Fluorodeoxyglucose (FDG) kinetics in cancer has been most often limited to the evaluation of the average uptake over relatively large volumes. Nevertheless, tumor lesions also contain inflammatory infiltrates whose cells are characterized by a significant radioactivity washout due to the hydrolysis of FDG-6P catalyzed by glucose-6P phosphatase. The present study aimed to verify whether voxel-wise compartmental analysis of dynamic imaging can identify tumor regions characterized by tracer washout.
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