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Oral Microbiota in Severe Early Childhood Caries in Thai Children and Their Families: A Pilot Study. | LitMetric

Oral Microbiota in Severe Early Childhood Caries in Thai Children and Their Families: A Pilot Study.

Front Microbiol

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.

Published: October 2018

Thailand has a comparatively high prevalence of severe early childhood caries (S-ECC). S-ECC adversely affects the quality of life for children and their caregivers and represents a considerable economic burden. We have assessed the bacteriological composition of unstimulated saliva, dental plaque, and degraded dentine in a Thai cohort, including children with S-ECC and children without cavities; their siblings, and their primary caregivers. Samples were collected during a dental examination and patients were scored for plaque accumulation and their decayed, missing, and filled teeth (dmft) index. Samples were analyzed using differential bacteriological counting and gel-based eubacterial DNA profiling. Plaque abundance correlated significantly with S-ECC. Whilst counts were significantly higher in children with S-ECC than in their siblings and primary caregivers (five families), the opposite trend was apparent for cavity-free children. Counts of Gram-negative anaerobes were significantly lower in children with S-ECC than orally healthy children. S-ECC correlated significantly with plaque index scores, dmft, and with abundance in a highly predictive manner. DNA profiles showed significant homology between families but not within non-cavity and S-ECC groups. In conclusion, salivary and plaque counts were significantly associated with S-ECC in the Thai subjects. counts in the children were not correlated with those of their siblings and primary caregivers. Individuals could be significantly differentiated based on family but not on caries status.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196314PMC
http://dx.doi.org/10.3389/fmicb.2018.02420DOI Listing

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