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Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug.
Pharmaceuticals (Basel)
January 2025
Service Pharmacie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), 149 Rue de Sèvres, F-75015 Paris, France.
Unlabelled: Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.
Objectives: The aim of the study was to develop and characterize an optimal ODF formulation containing equivalent hydrocortisone at 0.
Effects of a Footbathing Intervention on Physiological, Endocrine, and Psychological Status in Japanese University Students: A Randomized Controlled Trial.
Int J Environ Res Public Health
December 2024
Faculty of Letters, Arts and Sciences, Waseda University, Tokyo 162-8644, Japan.
The present pilot study examined effectiveness of a 2-week footbathing intervention on physiological, endocrine, and psychological status in healthy Japanese university students. A total of 51 participants were randomly assigned to a footbathing or normal bathing group. Participants in both groups provided daily free descriptions of their physical and mental states during the intervention period.
View Article and Find Full Text PDFTHE RATIO OF EXCITATORY AND INHIBITORY SYNAPTIC PROCESSES IN NEURONS OF THE ЕNTORHINAL CORTEX OF THE BRAIN, ACTIVATED BY BASOLATERAL AMYGDALA ON THE MODEL OF PARKINSON'S DISEASE, UNDER CONDITIONS OF PROTECTION BY HYDROCORTISONE.
Georgian Med News
November 2024
2Institute of Botany after A. Takhtajyan NAS RA, Yerevan, Armenia.
Parkinson disease (PD) is a common neurodegenerative condition. It affects the central nervous system, and it impairs cognitive processes, motor skills and other functions. The aim of this study was to determine the synaptic processes in medial Entorhinal cortex (mENT) under High frequency stimulation of Basolateral Amygdala on the model of Parkinson's disease under the influence of Hydrocortisone.
View Article and Find Full Text PDFRisperidone-Induced Hypothermia in a Cerebral Palsy Patient: A Case Report and Literature Review.
Cureus
December 2024
Internal Medicine, King Abdulaziz Specialist Hospital, Taif, SAU.
Cerebral palsy (CP) is a debilitating disorder that can lead to life-long disability, with a high incidence in Saudi Arabia. Secondary epilepsy and cardiac complications are common in CP patients. We present a rare case of a 17-year-old female with CP, attention-deficit hyperactivity disorder (ADHD), secondary epilepsy, and a history of post-cardiac arrest, with home medications carbamazepine, risperidone, and sodium valproate.
View Article and Find Full Text PDFCortisol regulates neonatal lung development via Smoothened.
Respir Res
January 2025
National Clinical Research Center for Aging and Medicine, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Background: Neonatal respiratory distress syndrome (NRDS), one of the main causes of neonatal death, is clinically characterized by progressive dyspnea and cyanosis 1 to 2 h after birth. Corticosteroids are commonly used to prevent NRDS in clinical. However, the protective mechanism of the corticosteroids remains largely unclear.
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