AI Article Synopsis

  • The study assesses the impact of Austria's TFA regulation (introduced in 2009) on cardiovascular disease (CVD) outcomes, comparing death rates before (1995-2009) and after (2010-2014) the intervention.
  • Despite expectations, there was no significant effect of the TFA regulation on CVD-related mortality trends in Austria, as both the local population and an international comparator group showed continuous decreases in death rates.
  • The findings suggest that while the TFA regulation did not lead to an obvious reduction in CVD mortality, it still plays a role in reducing health risks and should remain a part of public health strategies against non-communicable diseases.

Article Abstract

Background: Unhealthy diet, especially consumption of trans fatty acids (TFAs), is a known risk factor for cardiovascular disease (CVD), a leading cause of death in Austria. In 2009, Austria introduced a law regulating the content of TFAs in foods. The aim of this study was to assess the impact of the TFA regulation on CVD-related outcomes.

Methods: The study evaluated the TFA regulation as an intervention in a natural experiment. Two study periods were assessed: pre-intervention (1995-2009) and post-intervention (2010-14). The study compared the age-standardized death rates per 100 000 population for CVD outcomes with those of a 'synthetic' international comparator population, created from data of OECD countries where TFA regulation has not been implemented, but where the population is otherwise comparable.

Results: There was a continuous decrease in CVD-related mortality throughout the study period in both the synthetic international comparator population, as well as in the adult Austrian population, with no significant change in this trend observed as an effect of TFA regulation.

Conclusions: Whilst the results are counterintuitive, given the established link between TFA consumption and an increased risk of CVD, there are many possible explanations: high prevalence of tobacco smoking, changes in TFA content in foods due to international guidance as opposed to formal regulation and a beneficial impact of TFA regulation on sub-groups of the population that might not be detected with nationally aggregated data. However, reduction in TFAs should still be considered an important part of risk factor reduction for CVD and other non-communicable diseases.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204548PMC
http://dx.doi.org/10.1093/eurpub/cky147DOI Listing

Publication Analysis

Top Keywords

tfa regulation
16
trans fatty
8
fatty acids
8
risk factor
8
impact tfa
8
international comparator
8
comparator population
8
tfa
7
regulation
6
population
6

Similar Publications

Dietary intakes of trans fatty acids before the prohibition of partially hydrogenated oils in Canada.

Eur J Nutr

December 2024

Nutrition Research Division, Bureau of Nutritional Sciences, Health Products and Food Branch, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON, K1A 0K9, Canada.

Purpose: Canada's public health objective is that ≥ 90% of the population consume <1% of total energy (< 1%En) as trans fatty acids (TFA), in line with World Health Organization recommendations. Our study aimed to estimate usual intakes of total TFA, industrially-produced TFA (i-TFA), and naturally occurring TFA (n-TFA) overall and in subgroups of the population before Canada's 2018 prohibition on the use of partially hydrogenated oils (PHO) in foods.

Methods: Data from 1-2 24-h recalls was available for 19,670 participants in the cross-sectional Canadian Community Health Survey (CCHS)-Nutrition 2015.

View Article and Find Full Text PDF

Achieving Uniform Deposition of Zn with Amide Additives for Metal Anodes Stabilization.

ACS Appl Mater Interfaces

December 2024

School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.

The practical applications of aqueous zinc-ion batteries (AZIBs) are hindered by detrimental effects such as dendrites formation at the Zn metal anode interface and parasitic side reactions induced by HO. Hence, we propose adding amide additives to the Zn sulfate electrolyte (ZSO) to regulate the composition and properties of the electrolytes, thereby stabilizing the Zn anode interface. Different amide molecules containing formamide (FA), acetamide (AA), or trifluoroacetamide (TFA) are discussed.

View Article and Find Full Text PDF

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis.

Cell Metab

January 2025

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. Electronic address:

Dietary fat drives the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), particularly through circulating cholesterol and triglyceride-rich lipoprotein remnants. Industrially produced trans-unsaturated fatty acids (TFAs) incorporated into food supplies significantly promote ASCVD. However, the molecular trafficking of TFAs responsible for this association is not well understood.

View Article and Find Full Text PDF
Article Synopsis
  • PFASs are a group of man-made chemicals, and ultrashort-chain PFAAs have become a focus due to their environmental impact and prevalence.
  • A literature database from 1990 to 2024 reveals that these ultrashort-chain PFAAs, particularly TFA, are widely found in various environments and often at higher concentrations than longer-chain PFASs.
  • The review also indicates that ultrashort-chain PFAAs are present in many living organisms, including humans, and emphasizes the need for research and regulation due to their increasing significance in environmental health discussions.
View Article and Find Full Text PDF

Blood biomarkers of trans-fatty acid intake among Nigerian adults in the Federal Capital Territory: a cross-sectional study.

Am J Clin Nutr

January 2025

Cardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; Department of Internal Medicine, Faculty of Clinical Sciences, University of Abuja, Abuja, Nigeria.

Background: Intake of trans-fatty acids (TFAs) is an established risk factor for cardiovascular disease. In April 2023, Nigeria passed regulations limiting TFA content in foods, fats, and oils, but the current level of TFA exposure in the Nigerian population is unknown.

Objectives: To quantify trans-fatty acid (TFA) biomarkers in dried blood spots from Nigerian adults in the Federal Capital Territory before policy enforcement, establish baseline levels for future evaluations, assess subgroup variations by demographic and socioeconomic factors, and compare TFA levels with data from 30 countries worldwide.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!