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| http://dx.doi.org/10.1161/JAHA.118.010508 | DOI Listing |
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The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial.
Osteoarthr Cartil Open
March 2025
Brigham and Women's Hospital, Boston, MA, USA.
Objective: Given the high burden and increasing prevalence of post-traumatic osteoarthritis (PTOA), identifying clinically beneficial strategies to prevent or delay its onset could improve the quality of life of those at high risk of developing the disease.
Methods: Preventing Injured Knees from OsteoArthritis: Severity Outcomes (PIKASO) is a multicenter blinded, parallel, two-arm randomized controlled trial of 512 individuals aged 18-45 years undergoing anterior cruciate ligament reconstruction (ACLR). This study is designed to evaluate the efficacy of a 12-month intervention of oral metformin vs.
Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms.
BMC Rheumatol
January 2025
Department of Clinical Sciences, Diagnostic Radiology, Lund, Lund University, Lund, Sweden.
Background: Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal lobe (MTL) regions. Our study aims to compare MTL subregional volumes in SLE patients to healthy individuals (HI) and explore MTL subregional volumes in relation to neuropsychiatric SLE (NPSLE) manifestations.
View Article and Find Full Text PDFFlood change detection model based on an improved U-net network and multi-head attention mechanism.
Sci Rep
January 2025
School of Transportation and Geometics Engineering, Yangling Vocational & Technical College, Yangling, 712100, Shaanxi, China.
This work aims to improve the accuracy and efficiency of flood disaster monitoring, including monitoring before, during, and after the flood, to achieve accurate extraction of flood disaster change information. A modified U-Net network model, incorporating the Transformer multi-head attention mechanism (TM), is developed specifically for the characteristics of Synthetic Aperture Radar (SAR) images. By integrating the TM, the model effectively prioritizes image regions relevant to flood disasters.
View Article and Find Full Text PDFPost-operative hemorrhage in patients with aneurysms associated with arteriovenous malformations. A Systematic Review and meta-analysis.
World Neurosurg
January 2025
Department of Neurologic Surgery, Pontificia Universidad Javeriana, Neurosurgery Research Group.
Objective: To compare the rates of postoperative hemorrhages for aneurysms associated with brain AVM evaluating the lesion that was initially treated.
Methods: A systematic review of the literature was carried out following the PRISMA guidelines. The search was performed in PubMed, Embase and Scopus .
A European Delphi Consensus on the Management of Abdominal Aortic Aneurysms in Patients with Heritable Aortic Diseases.
Eur J Vasc Endovasc Surg
January 2025
Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; Department of Vascular, Endovascular Surgery and Angiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address:
Objective: Abdominal aortic aneurysm (AAA) in a patient with an underlying heritable aortic disease (HAD) is rare, and evidence based recommendations for its management are lacking. This study aimed to generate a consensus from multidisciplinary specialists on the diagnosis, treatment, and surveillance of AAA associated with HAD and to define topics of interest for future research.
Methods: A Delphi consensus was designed involving European multidisciplinary specialists and reported using the ACcurate COnsensus Reporting Document (ACCORD) reporting guideline.
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