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Cancer-specific utility instrument for health economic evaluations: A synopsis of the EORTC QLU-C10D user manual and current validity evidence.
Eur J Cancer
January 2025
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility - Core 10 Dimensions (QLU-C10D) adds a preference-based scoring algorithm to the EORTC measurement portfolio. It is built on the most widely used health-related quality of life (HRQoL) measure in oncology, the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30), allowing for the calculation of both HRQoL profiles and health utilities. This is an important advancement for integrating cancer-specific values into health economic evaluations and decision making, offering greater content validity and statistical power than some generic measures.
View Article and Find Full Text PDFEffects of the RNA-Binding Protein Sam68 on Poly(ADP-Ribose)polymerase 1 Activity.
Biochemistry (Mosc)
December 2024
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Taking into account involvement of the RNA-binding proteins in regulation of activity of poly(ADP-ribose) polymerase 1 (PARP1), a key factor of DNA repair, the effect of the intrinsically disordered protein Sam68 (Src-associated substrate during mitosis of 68 kDa) on catalytic activity of this enzyme was studied. Plasmid containing coding sequence of the Sam68 protein was obtained. Using the obtained construct, conditions for the Sam68 expression in cells were optimized and procedure for protein purification was developed.
View Article and Find Full Text PDFResearch on the Performance of a Liquid-Solid Triboelectric Nanogenerator Prototype Based on Multiphase Liquid.
Micromachines (Basel)
January 2025
College of Naval Architecture and Shipping, Guangdong Ocean University, Zhanjiang 524088, China.
In recent years, liquid-solid triboelectric nanogenerators (L-S TENGs) have been rapidly developed in the field of liquid energy harvesting and self-powered sensing. This is due to a number of advantages inherent in the technology, including the low cost of fabricated materials, structural diversity, high charge-energy conversion efficiency, environmental friendliness, and a wide range of applications. As liquid phase dielectric materials typically used in L-S TENG, a variety of organic and inorganic single-phase liquids, including distilled water, acidic solutions, sodium chloride solutions, acetone, dimethyl sulfoxide, and acetonitrile, as well as paraffinic oils, have been used in experiments.
View Article and Find Full Text PDFOptimizing laboratory medication safety monitoring in patients with juvenile idiopathic arthritis to advance value-based care.
Clin Rheumatol
January 2025
Children's Mercy Kansas City, Kansas City, MO, USA.
Introduction/objectives: Most children with juvenile idiopathic arthritis (JIA) are treated with medications that require safety monitoring labs. Recommended testing includes a creatinine level. However, 87.
View Article and Find Full Text PDFGrain-Boundary Corrosion in UO from a Defect Chemical Perspective: A Case Study of the Σ5(310)[001] Grain Boundary.
ACS Appl Mater Interfaces
January 2025
Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52074 Aachen, Germany.
We combine atomistic and continuum simulation methods to study the defect chemistry of a model grain boundary in UO. Using atomistic methods, we calculate the formation energies of oxygen interstitials, uranium vacancies, and hole polarons (U ions) across the Σ5(310)[001] symmetric tilt grain boundary. This information is then used as input in a continuum model of point-defect concentrations at the grain boundary and in its vicinity, taking into account electrostatic (space-charge) effects.
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