AI Article Synopsis
- The study investigates the role and significance of endothelial microparticles (EMPs) in children diagnosed with Henoch-Schönlein purpura (HSP), a condition that can affect the kidneys.
- It compares groups of children with HSP, some having nephritis (inflammation of the kidneys) and others without, against a control group of healthy children, measuring levels of Th17 cells, interleukin-17 (IL-17), and EMPs.
- Results show that children with nephritis have the highest levels of Th17, IL-17, and EMPs, suggesting that elevated EMP levels may contribute to kidney issues in those with HSP.
Article Abstract
Objective: To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).
Methods: A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups.
Results: The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P<0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P<0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P<0.05).
Conclusions: EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389040 | PMC |
| http://dx.doi.org/10.7499/j.issn.1008-8830.2018.10.009 | DOI Listing |
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