The approach in the clinical fluid management of the dying is still controversially discussed in specialist circles and also in the general population. In this article the importance of establishing the therapeutic indications is emphasized against the background of a lack of evidence. Options to achieve noninvasive objectification of assumed dehydration as well as assessment of the reversibility of the symptoms are shown and the importance of monitoring of all therapeutic actions is discussed. The pathophysiological foundation of reversible disorders of fluid homoeostasis are described and distinguished from the irreversible disorders leading to terminal dehydration. If clinically assisted hydration (CAH) is indicated, the hydration status must be assessed individually as well as in advance and all therapeutic measures must be constantly adjusted to the results of non-invasive monitoring procedures.
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Am J Hosp Palliat Care
January 2025
Graduate School of Medicine, Mie University, Tsu, Japan.
Background: Delirium is a condition characterized by an acute and transient disturbance in attention, cognition, and consciousness. It is increasingly prevalent at the end of life in patients with cancer. While non-pharmacological nursing interventions are essential for delirium prevention, their effectiveness in terminally ill patients with cancer remains unclear.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Université Côte d'Azur, CNRS, Inserm, Institut Biologie Valrose, Nice, France; Laboratory of Excellence for RBC, LABEX GR-Ex, Paris, France. Electronic address:
KCNN4, a Ca-activated K channel, is involved in various physiological and pathological processes. It is essential for epithelial transport, immune system, and other physiological mechanisms, but its activation is also involved in cancer pathophysiology as well as red blood cell (RBC) disorders. The activation of KCNN4 in RBC leads to loss of KCl and water, a mechanism known as the "Gardos effect" described 70 years ago.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
School of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, 550014 Guiyang, P. R. China.
This study presents a highly efficient method for 4-aminoquinoline derivative preparation under transition metal-free conditions. The process involves an aerobic oxidative dehydrative coupling of 2,3-dihydroquinolin-4(1)-ones with various amines, including ammonia, resulting in high yields of the desired products. The method is also applicable to substituted 4-aminoquinoline derivative construction through a cyclization/dehydrative coupling cascade process starting from 2'-amino chalcones.
View Article and Find Full Text PDFPhys Chem Chem Phys
October 2024
Key Laboratory of Green Chemistry and Technology, Ministry of Education, National and Local Joint Engineering Laboratory of Energy Plant Biofuel Preparation and Utilization, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China.
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