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Concomitant formation of protocells and prebiotic compounds under a plausible early Earth atmosphere.
Proc Natl Acad Sci U S A
January 2025
Laboratory of Crystallographic Studies, Instituto Andaluz de Ciencias de la Tierra, Consejo Superior de Investigaciones Científica, Armilla 18100, Spain.
Revealing the origin of life and unambiguously detecting fossil remains of the earliest organisms are closely related aspects of the same scientific research. The synthesis of prebiotic molecular building blocks of life and the first compartmentalization into protocells have been considered two events apart in time, space, or both. We conducted lightning experiments in borosilicate reactors filled with a mixture of gases mimicking plausible geochemical conditions of early Earth.
View Article and Find Full Text PDFThe ability of pentose pathways to form all essential metabolites provides clues to the origins of metabolism.
PLoS Biol
January 2025
Department of Biochemistry, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.
The structure of the early metabolic network is unknown. Here, we report that when considered together, pentose utilization pathways form all life-essential precursors. We speculate that the chemistry preserved in pentose metabolism could therefore have been a central structural element in early metabolism.
View Article and Find Full Text PDFEpidemiology of Soft Tissue Sarcoma in Iran: Four-Year National Cancer Registry Data Report (2014-2017).
Cancer Rep (Hoboken)
January 2025
MD, Assistant Professor in Community Medicine, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Introduction: An uncommon and diverse class of cancers originating from mesenchymal tissues is designated as soft tissue sarcoma (STS). To develop effective preventive and treatment strategies for STS, it is essential to gain a deeper understanding of the epidemiological trends associated with the disease. This research will analyze the 4-year age-standardized incidence rate (ASIR) and geographical distribution of STS in Iran in great detail.
View Article and Find Full Text PDFObjective: The November through January holiday period is often thought to produce weight gain, coined "holiday weight gain." While this trend has been documented among early to midlife adults, it is less certain whether college students experience similar levels of weight gain during this period, as they undergo lifestyle changes (e.g.
View Article and Find Full Text PDFEarly development of the calcified exoskeleton of the polyplacophoran mollusk, with insight into the evolutionary history of shell plates and spicules.
Dev Growth Differ
January 2025
Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Recent molecular phylogenetic studies have raised two questions about the evolutionary history of the calcified exoskeleton of mollusks. The first question concerns the homology of the two types of skeleton: whether spicules and shell plates share an evolutionary origin. The second question is the homology of the shell plates between chitons and other mollusks, including gastropods and bivalves.
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