AI Article Synopsis
- The study examines viral co-detection in children with severe acute respiratory infections during the 2009 H1N1 pandemic in Rio de Janeiro.
- Of the 71 respiratory samples analyzed, 38% tested positive for H1N1, with a variety of other viruses also detected, indicating that co-infection is common.
- H1N1-positive patients showed specific clinical features but there were no significant differences in the severity of illness or outcomes between those with multiple viral detections and those with a single virus.
Article Abstract
Objectives: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic.
Method: Longitudinal observational retrospective study, with patients aged 0-18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009. The results of respiratory samples which were sent to the Laboratory of Fiocruz/RJ and clinical data extracted from specific forms were analyzed.
Results: Of 71 samples, 38% tested positive for H1N1 virus. Of the 63 samples tested for other viruses, 58 were positive: influenza H1N1 (43.1% of positive samples), rhinovirus/enterovirus (41.4%), respiratory syncytial vírus (12.1%), human metapneumovirus (12.1%), adenovirus (6.9%), and bocavirus (3.5%). Viral codetection occured in 22.4% of the cases. H1N1-positive patients were of a higher median age, had higher frequency of fever, cough and tachypnea, and decreased leukometry when compared to H1N1-negative patients. There was no difference in relation to severity outcomes (number of organic dysfunctions, use of mechanical ventilation or amines, hospital/PICU length of stay or death). Comparing the groups with mono-detection and co-dection of any virus, no difference was found regarding the association with any clinical variable.
Conclusions: Other viruses can be implicated in SARI in children. The role of viral codetection has not yet been completely elucidated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138071 | PMC |
| http://dx.doi.org/10.1016/j.bjid.2018.09.001 | DOI Listing |
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