Objective: to understand the feelings of families before drug dependence.
Method: exploratory, analytical and qualitative study carried out with families of drug users, which are followed up by the Centro de Atenção Psicossocial Álcool e Drogas (Psychosocial Care Center for Alcohol and DARUGS). The collection of data took place by in-depth interview, with the support of field diary. Three visits were done, on average, for each family. The software IRAMUTEQ was adopted for textual corpus organization and was discussed in the light of Michel Maffesoli.
Results: nine families participated in the research; from the analysis, four classes arose: "My life has changed a lot because of drugs"; "I fear leaving him alone"; "I trust and have faith in God", and "I am always worried in my own house".
Final Considerations: the families revealed how much drug dependence did not only affect the user, but also the whole family, provoking in the family complex feelings and emotions.
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http://dx.doi.org/10.1590/0034-7167-2018-0150 | DOI Listing |
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CD8T cells within the tumor microenvironment (TME) are often functionally impaired, which limits their ability to mount effective anti-tumor responses. However, the molecular mechanisms behind this dysfunction remain incompletely understood. Here, we identified valosin-containing protein (VCP) as a key regulator of CD8T cells suppression in hepatocellular carcinoma (HCC).
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Faculty of Philosophy, University of Oxford, Oxford, UK
Semaglutide, sold under the brand names of Ozempic, Rybelsus and Wegovy, is one of the most popular drugs on the market. Manufactured by Novo Nordisk, semaglutide is the newest in a family of glucagon-like peptide-1 receptor agonists used most commonly to treat type II diabetes. To date, the results of semaglutide for the treatment of type II diabetes have been overwhelmingly positive.
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Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea.
(LE), a medicinal plant from the Boraginaceae family, is traditionally used in East Asia for its therapeutic effects on skin conditions, including infections, inflammation, and wounds. Recently, the role of extracellular vesicles (EVs) as mediators of intercellular communication that regulate inflammation and promote tissue regeneration has garnered increasing attention in the field of regenerative medicine. This study investigates exosome-like vesicles derived from LE callus (LELVs) and their potential in enhancing wound healing.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt. Electronic address:
Chemotherapy-induced cognitive impairment, referred to as "chemobrain", is widely acknowledged as a significant adverse effect of cancer therapy. Paclitaxel, a chemotherapeutic drug, has been reported to cause cognitive impairment clinically and in animal models. However, the precise mechanisms are not fully understood.
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