AI Article Synopsis
- Pancreatic cancer is a deadly disease with specific precursor lesions that are important for understanding its development.
- These precursors include various types of neoplasms that have unique characteristics and molecular changes.
- The review seeks to highlight key points about how pancreatic cancer develops, recent research advancements, and future directions in the study of this serious type of cancer.
Article Abstract
Pancreatic cancer is a lethal malignancy, whose precursor lesions are pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm. To better understand the biology of pancreatic cancer, it is fundamental to know its precursors and to study the mechanisms of carcinogenesis. Each of these precursors displays peculiar histological features, as well as specific molecular alterations. Starting from such pre-invasive lesions, this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer, with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198304 | PMC |
| http://dx.doi.org/10.4251/wjgo.v10.i10.317 | DOI Listing |
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