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Cross-Reactivity of Insulin Immunoassays Important for Insulin Analogue Detection in Factitious Hypoglycaemia.
Indian J Endocrinol Metab
June 2024
Department of Endocrinology and Metabolism, AIIMS, New Delhi, India.
Insights into insulin analog cross-reactivity: a comparative study of Siemens Atellica and LC-MS/MS.
Endocrine
January 2025
Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Background: To address the challenges posed by inconsistent detection of analog insulin in commercially available insulin immunoassays, resulting in potential discrepancies in clinical findings and misdiagnosis during the investigation of factitious hypoglycemia., we aimed to evaluate the ability of the Siemens Atellica automated immunoassay to detect insulin analogs compared with LC-MS/MS.
Methods: Five insulin analogs were analyzed at 10 ng/mL spiked into serum samples, with recombinant human insulin as positive controls.
Hypoglycemia in non-diabetic in-patients at a teaching referral hospital in Iran.
J Diabetes Metab Disord
June 2024
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- This study examined non-diabetic patients with hypoglycemia to understand their comorbid conditions, symptoms, lab results, and diagnoses.
- Conducted at Shariati Hospital in Iran from 2016 to 2023, it analyzed data from 74 non-diabetic patients, excluding those with diabetes and focusing on various factors related to their hypoglycemic episodes.
- The findings revealed that a significant portion experienced common symptoms like weakness and dizziness, with underlying causes including psychological disorders and organ failure, highlighting the need for timely diagnosis and treatment to avoid serious health consequences.
Insulin Abuse: A Case Report of Munchausen Syndrome.
Endocr Metab Immune Disord Drug Targets
June 2024
Abant Izzet Baysal University Internal Medicine Bolu Turkey.
Article Synopsis
- Hypoglycaemia in diabetes involves abnormal glucose levels accompanied by symptoms, while Munchausen Syndrome (MS) entails individuals intentionally faking symptoms for secondary gain.
- The report discusses a case of a 28-year-old woman with type I diabetes who repeatedly induced hypoglycemia attacks to seek unnecessary medical attention.
- Understanding Munchausen Syndrome is crucial for healthcare providers to avoid misdiagnosing patients and to prevent costly and unnecessary medical procedures.
Clinical Presentation, Diagnosis, and Management of Hyperinsulinemic Hypoglycemia in Adults: A Single-center Experience.
Endocr Metab Immune Disord Drug Targets
May 2024
Internal Medicine Unit, Section of Endocrinology, ENETS Center of Excellence, University Hospital of Verona, Italy.
Introduction: Hyperinsulinemic Hypoglycemia (HH) is a rare condition characterized by inappropriately elevated insulin levels in the presence of low glucose levels. A proper diagnostic framework is fundamental to avoid patients undergoing unnecessary diagnostic and therapeutic invasive procedures.
Objective: The study aimed to assess the clinical presentation, diagnostic work-up, and treatment of a single-center cohort of patients affected by HH.
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