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| http://dx.doi.org/10.1002/mdc3.12026 | DOI Listing |
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Treatment with OnabotulinumtoxinA for Oromandibular Dystonia: A Systematic Review and Meta-Analysis.
Toxins (Basel)
December 2024
Department of Neurology, Tokushima University, Tokushima 770-8503, Japan.
Article Synopsis
- Oromandibular dystonia (OMD) is a condition causing muscle contractions in the jaw and related areas, and this study analyzed the effects of botulinum toxin (onabotulinumtoxinA) as a treatment.
- A meta-analysis of 26 studies with 1103 patients showed that 96.2% experienced a positive response to the injections, with 88.9% achieving significant improvement of over 50%.
- Although 17.8% of patients had adverse effects, mainly dysphagia (10.1%), the overall findings suggest that botulinum toxin is an effective treatment for OMD but further studies are needed for more conclusive results.
External Factors Modulating Pain and Pain-Related Functional Impairment in Cervical Dystonia.
Mov Disord Clin Pract
December 2024
University of Calgary, Department of Clinical Neurosciences, Faculty of Medicine, Calgary, Alberta, Canada.
Background: Little is known about factors modulating pain and pain-related functional impairment in isolated cervical dystonia (CD).
Objective: The aim was to assess the prevalence and interrelationship between pain-modulating factors and pain-related determinants of functional impairment and quality of life in CD.
Methods: We analyzed pain-aggravating and pain-relieving external factors, the degree of pain-related functional impact on routine activities, and the relationship between these and pain severity, using cross-sectional data collected using the Pain in Dystonia Scale (PIDS) from 85 participants with CD.
Effectiveness of Electroconvulsive Therapy in Functional Neurological Disorders: A Case Report.
Actas Esp Psiquiatr
August 2024
Doctor, Psychiatrist, Directora Médica de Emooti. Centro Avanzado en Bienestar Emocional, 28010 Madrid, Spain.
Electroconvulsive therapy is a type of therapy frequently used in psychiatric clinical practice. Although it is generally used for the treatment of affective disorders or severe and/or resistant psychotic disorders, it has also demonstrated its usefulness in many other neuropsychiatric conditions. We present the case of a 26-year-old woman, previously diagnosed with a functional neurological disorder-with fixed dystonia phenotype in the right upper limb-, admitted to our hospital for a severe depressive episode.
View Article and Find Full Text PDFPhenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase: 3 and .
eNeuro
August 2024
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
is a Na,K-ATPase gene expressed specifically in neurons in the brain. Human mutations are dominant and produce an unusually wide spectrum of neurological phenotypes, most notably rapid-onset dystonia parkinsonism (RDP) and alternating hemiplegia of childhood (AHC). Here we compared heterozygotes of two mouse lines, a line with little or no expression (3) and a knock-in expressing p.
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