Background: Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the () gene.
Methods: This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search.
Results: There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD- carriers, compared to noncarriers. PD- carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD- carriers may also have a more aggressive motor phenotype than noncarriers.
Conclusions: Early identification of PD- carriers may lead to targeted therapies and development of new treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178756 | PMC |
| http://dx.doi.org/10.1002/mdc3.12229 | DOI Listing |
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