AI Article Synopsis
- Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting multiple organs, including the eyes, skin, and inner ear, leading to symptoms such as uveitis, retinal detachment, and hearing loss.
- An MRI using gadolinium-enhanced 3D FLAIR imaging can reveal significant abnormalities like bilateral enhancement in the inner ears and leptomeninges, aiding in the diagnosis.
- A case study of a 36-year-old female highlights the diagnostic effectiveness of this imaging technique, showcasing its superiority over traditional MRI methods in detecting leptomeningeal and inner ear involvement.
Article Abstract
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder that occurs in the melanocytes present in the uvea, leptomeninges, skin and inner ear. Clinically, this disease is characterized by bilateral uveitis and retinal detachment and is associated with meningismus and hearing loss. Gadolinium (Gd)-enhanced MRI may aid in demonstrating bilateral choroidal thickening and central nervous system involvement. We present a case of VKH where Gd-enhanced three-dimensional (3D) fluid attenuation inversion recovery (FLAIR) imaging showed abnormal bilateral enhancement in the inner ears. A 36-year-old female was referred to our institution with symptoms of visual disturbance, headache and tinnitus, and was diagnosed with VKH based on fundus examination and clinical presentations. MRI findings revealed bilateral enhancement in the choroid, leptomeninges, and inner ears. In particular, Gd-enhanced 3D FLAIR showed more conspicuous enhancement of the leptomeninges and inner ear compared with Gd-enhanced 3D weighted image. Therefore, Gd-enhanced 3D FLAIR imaging can be used when leptomeningeal or inner ear pathology is clinically suspected.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159301 | PMC |
| http://dx.doi.org/10.1259/bjrcr.20160090 | DOI Listing |
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