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Familial hypercholesterolemia in Gran Canaria: Founder mutation effect and high frequency of diabetes.
Clin Investig Arterioscler
January 2022
Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, España; Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, España.
Introduction: Gran Canaria is a region of genetic isolation of familial hypercholesterolemia due to a founder mutation, p. [Tyr400_Phe402del], in the LDL receptor (LDLR) gene. Initial data suggest that its carriers could have a high prevalence of diabetes.
View Article and Find Full Text PDF[Hipercolesterolemia: un efecto metabólico después del bypass gástrico que aún falta por definir].
Cir Cir
January 2018
Servicio de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Ciudad de México, México.
Introducción: la hipercolesterolemia es uno de los principales factores de riesgo en la enfermedad cardiovascular. Los esteroles vegetales se han postulado como agentes reguladores y beneficiosos para el control de esta.Objetivo: analizar el efecto de los esteroles vegetales añadidos en una leche en la reducción del colesterol plasmático en adultos jóvenes.
View Article and Find Full Text PDF[Effects of atorvastatin in N-terminal pro-brain natriuretic peptide plasma levels in hypercholesterolemic patients with or without hypertension].
Med Clin (Barc)
October 2006
Unidad de Riesgo Vascular, Servicio de Medicina Interna, Hospital San Pedro de Alcántara, Cáceres, Spain.
Background And Objective: N-terminal pro-brain natriuretic peptide (NT-proBNP) is a useful predictor of cardiovascular events in patients without clinical evidence of cardiovascular disease. It is unknown if the cardiovascular risk factors control can modify these levels. We studied if atorvastatin treatment decrease NT-proBNP levels in hypercholesterolemic subjects, with and without hypertension.
View Article and Find Full Text PDF[A randomized single-blind trial of the effects of vitamins C and E in familial hypercholesterolemia].
An Pediatr (Barc)
August 2006
Departamento de Pediatría, División de Metabolismo, Hospital de Cruces y Facultad de Medicina de la Universidad del País Vasco, Baracaldo, España.
Introduction: The aim of this study was to evaluate the effect of antioxidant vitamin C and E administration on dyslipidemia, plasma fatty acid composition, and biochemical inflammatory markers in children with heterozygous familial hypercholesterolemia (FH).
Patients: Forty girls and boys with heterozygous FH, aged between 2 and 18 years, and with plasma low-density lipoprotein (LDL)-cholesterol levels higher than 160 mg/dl were studied.
Methods: We performed an open longitudinal randomized trial over a 1-year period.
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