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Circulating large extracellular vesicles as diagnostic biomarkers of indeterminate thyroid nodules: multi-platform omics analysis.
BJS Open
December 2024
Institute of Cardiovascular Sciences, University College London, London, UK.
Background: While most thyroid nodules are benign, 7-15% are malignant. Patients with indeterminate thyroid nodules (specifically Bethesda IV/Thy3f) often undergo diagnostic hemithyroidectomy to reach a diagnosis on final histology. The aim of this study was to assess the feasibility of circulating large extracellular vesicles as diagnostic biomarkers in patients presenting with Thy3f thyroid nodules.
View Article and Find Full Text PDFInvestigations into the growth and formation of biofilm by at temperatures encountered during infection.
Biofilm
June 2025
Infectious Bacterial Diseases Research Unit, USDA Agriculture Research Service, National Animal Disease Center, Ames, IA, USA.
The genus comprises unique atypical spirochete bacteria that includes the etiological agent of leptospirosis, a globally important zoonosis. Biofilms are microecosystems composed of microorganisms embedded in a self-produced matrix that offers protection against hostile factors. Leptospires form biofilms in rice fields and unsanitary urban areas, and while colonizing rodent kidneys.
View Article and Find Full Text PDFBackground: Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported a rapid expansion of the cardiac lymphatic network upon ischemic heart injury and proposed that cardiac lymphatics may attenuate tissue edema and inflammatory mechanisms after ischemic heart injury. Nevertheless, the mechanisms through which hypoxic conditions affect cardiac lymphangiogenesis and function remain unclear.
View Article and Find Full Text PDFFocal adhesions, reticular adhesions, flat clathrin lattices: what divides them, what unites them?
Am J Physiol Cell Physiol
January 2025
Department for Nanophysiology, RPTU University Kaiserslautern-Landau, Kaiserslautern, Germany.
Article Synopsis
- Most cells in multicellular organisms need to attach to their environment, using structures called cell-matrix or cell-cell adhesions for stability.
- Integrins are key transmembrane receptors that help form these adhesion complexes by connecting with extracellular matrix components and linking to the cell's cytoskeleton, allowing for signaling.
- Recent research reveals that different types of integrin complexes, once thought to be separate, are actually interconnected and can influence each other's formation and transformation, particularly focusing on the versatile αvß5 integrins.
Unraveling the potential of Epicatechin gallate from crataegus oxyacantha in targeting aberrant cardiac Ca2+ signalling proteins: an in-depth investigation for heart failure therapy.
J Biomol Struct Dyn
December 2024
Department of Bioinformatics, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
The cardiovascular sarcoplasmic reticulum (SR) calcium (Ca2+) ATPase is an imperative determinant of cardiac functionality. In addition, anomalies in Ca2+ handling protein and atypical energy metabolism are inherent in heart failure (HF). Moreover, Ca2+ overload in SR leads to mitochondrial matrix Ca2+ overload, which can trigger the generation of Reactive Oxygen Species (ROS), culminating in the triggering of the Permeability Transition Pore (PTP) and Cytochrome C release, resulting in apoptosis that leads to arrhythmias and numerous disorders.
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