Five new acylated aminooligosaccharides (⁻), together with one known related analogue (), were isolated from sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic -amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265919 | PMC |
| http://dx.doi.org/10.3390/md16110403 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapid Mining of Novel -Glucosidase and Lipase Inhibitors from sp. HO1518 Using UPLC-QTOF-MS/MS.
Mar Drugs
March 2022
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
A rapid and sensitive method using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) was applied for the analysis of the metabolic profile of acarviostatin-containing aminooligosaccharides derived from sp. HO1518. A total of ninety-eight aminooligosaccharides, including eighty potential new compounds, were detected mainly based on the characteristic fragment ions originating from quinovosidic bond cleavages in their molecules.
View Article and Find Full Text PDFAcylated Aminooligosaccharides from the Yellow Sea sp. HO1518 as Both α-Glucosidase and Lipase Inhibitors.
Mar Drugs
November 2020
Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Three new acylated aminooligosaccharide (-), along with five known congeners (-), were isolated from the marine-derived sp. HO1518. Their structures were fully elucidated by extensive spectroscopic analysis, mainly based on 1D-selective and 2D TOCSY, HSQC-TOCSY, and HRESIMS spectrometry measurements, and by chemical transformations.
View Article and Find Full Text PDFAcylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518.
Mar Drugs
October 2018
Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Five new acylated aminooligosaccharides (⁻), together with one known related analogue (), were isolated from sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!