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Isoxazole Derivatives as Regulators of Immune Functions. | LitMetric

Isoxazole Derivatives as Regulators of Immune Functions.

Molecules

Department of Organic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.

Published: October 2018

AI Article Synopsis

Article Abstract

In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal disease models corresponding to human clinical situations. Beneficial features of the described isoxazole derivatives include low toxicity and good bioactivity at low doses. In a majority of studies, the activities of investigated compounds were comparable or even higher than registered reference drugs. Whenever possible, a plausible mechanism of action of the investigated compounds and their potential therapeutic utility were proposed. Among the described compounds, particular attention was paid to the class of immune stimulators with a potential application in chemotherapy patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222914PMC
http://dx.doi.org/10.3390/molecules23102724DOI Listing

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