The aim of this study was to evaluate the antibacterial activity against and fibroblast viability of zirconia coated with glass ceramic powder containing Ag and F nanoparticles. Specimens were divided into eight groups depending on the glass ceramic powders: 5, 10, 15, 20 wt% of NaF and Ag, respectively. Adhesion of on glass-coated zirconia surface was evaluated by antimicrobial test. Fibroblast viability was examined by WST-8 assay. In result, the bacterial activity was reduced by 11.8%, 15.4% in Ag 10 wt% and 20 wt% groups. When 5~15 wt% of NaF was added, bacterial counts decreased to 4.2~65.4%, and when 20 wt% of NaF was added, the number of bacteria increased by 29.4%. Regardless of Ag and NaF content, all zirconia specimens showed cell viability above 70%. Within the limitations of this study, zirconia coated with glass ceramics powder containing Ag and NaF was found to reduce the adhesion of but had no influence on osteoblast activation.
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